viernes, 26 de junio de 2009

One step closer to end HIV life cycle

In order for viruses to reproduce, they must infect a cell, this part we understand. But do we really know how the most devastating of all Viruses and the smartest one of all times really works?

Once i was told that in order to provide an accurate answer i need to understand the question, and of course the subject. The HIV Virus is the ultimate question of our time and we need to be able to understand it if we want to be able to eradicate this threat.

Viruses are not technically alive: they are sort of like a brain with no body. In order to make new viruses, they must hi-jack a cell, and use it to make new viruses. Just as your body is constantly making new skin cells, or new blood cells, each cell often makes new proteins in order to stay alive and to reproduce itself. Viruses hide their own DNA in the DNA of the cell, and then, when the cell tries to make new proteins, it accidentally makes new viruses as well. HIV mostly infects cells in the immune system.

Scientists have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, miR29 plays a key role in controlling the HIV life cycle. The study suggests that HIV may have co-opted this cellular defense mechanism to help the virus hide from the immune system and antiviral drugs.

Replication: Once HIV binds to a cell, it hides HIV DNA inside the cell’s DNA: this turns the cell into a sort of HIV factory.

The microRNA miR29 suppresses translation of the HIV-1 genome by transporting the HIV mRNA to processing-bodies (P-bodies), where they are stored or destroyed. This results in a reduction of viral replication and infectivity.

Infection: Several different kinds of cells have proteins on their surface that are called CD4 receptors. HIV searches for cells that have CD4 surface receptors, because this particular protein enables the virus to bind to the cell. Although HIV infects a variety of cells, its main target is the T4-lymphocyte (also called the “T-helper cell”), a kind of white blood cell that has lots of CD4 receptors. The T4-cell is responsible for warning your immune system that there are invaders in the system.

Scientis think the virus may use this mechanism to modulate its own life cycle, and we can use this to our advantage in developing new drugs for HIV Retroviral therapies greatly reduce viral load but cannot entirely eliminate it. This interaction between HIV and miR29 may contribute to that inability. Perhaps, by targeting miR29, we can force HIV into a more active state and improve our ability to eliminate it.

The team of Scientist managed to looked at miR29 expression levels in infected and uninfected cells and found that miR29 expression was enhanced by HIV-1 infection. Blocking the activity of miR29 with interfering RNA resulted in increased replication and infectivity of the virus. The scientists tested the association of miR29 and HIV-1 by mutating both miR29 and its target region on the HIV virus. When either was altered, miR29s suppression of HIV replication and infectivity was reduced or eliminated. In addition, the team suppressed P-bodies in the cells and noted a similar effect. This suggests that HIV may use miRNAs to become dormant and escape immune response.

A.Vissuetti

42 comentarios:

Anónimo dijo...

小遊戲,情色視訊聊天室,4u成人,pc交友,尋夢園聊天聯盟,玩美女人影音秀,666成人,免費視訊,聊天,情色論壇,視訊,成人文學,成人電影,漫畫貼圖,情色自拍,美女遊戲,情色a片,成人遊戲,上班族聊天室,巨乳,成人論壇,嘟嘟貼圖區,美女寫真,ut聊天室,同志聊天室,色情小遊戲,貼圖區,哈比寬頻成人,嘟嘟成人,玩美女人,視訊交友,自拍貼圖,正妹計時器,情色a片,成人遊戲,上班族聊天室,巨乳,成人論壇,嘟嘟貼圖區,美女寫真,ut聊天室,

Anónimo dijo...

Necessity is the mother of invention..........................

Unknown dijo...

Interesting article. More and more DNA testing sites are covering viral threats and discovery. See here for more DNA information en Español.

Anónimo dijo...

This is a brilliant article. You have explained the whole science in such a simple manner that those who don't even know a bit of biological science can understand it. Great to know about HIV replication.
Home DNA Test

Anónimo dijo...

分享的朋友,在精不在多,分享的幸福就在下一秒 ..................................................

Anónimo dijo...

Custom makes all things easy~~加油哦........................................

Anónimo dijo...

只用微笑說話的人,才能擔當重任..................................................

Anónimo dijo...

一個人的價值,應該看他貢獻了什麼,而不是他取得了什麼......................................................

Anónimo dijo...

文章優,圖片美,就連回文都很有意思~~~ ........................................

Anónimo dijo...

先告訴自己希望成為什麼樣的人,然後一步一步實踐必要的步驟。........................................

Anónimo dijo...

知識可以傳授,智慧卻不行。每個人必須成為他自己。...............................................................

皮皮 dijo...

好文!值得一推~~加油哦!.............................................

Anónimo dijo...

微風成人 ut視訊交友 彩虹聊天 a免費線上 手機視訊交友 女優露點影片 性感車展美女 av影片下載 走光+偷拍+自拍 彩虹視訊聊天室 85cc 情趣 18h 可愛視訊少女 85ccst影城 歐美a片論壇 007情色小說 自拍色情圖 彰化一夜情聊天室 s383影城 完美女人工廠 影音視訊聊天 做愛美女 視訊辣妹網 人妻自拍 歐美熟女做愛成人 視訊成人網 空姐性愛影片 aa圖免費看 美女寫真貼圖 85cc免費成人 成人短片 情色貼圖 視訊聊天 杜蕾斯貼圖區正妹牆 正妹援交 嘟嘟情人色網貼圖 鋼管秀 avvcd 洪爺影片城 國中大奶f sex888免費影片 色遊戲下載區 巨乳人妻影片 性貼圖 後宮 限制級遊戲 0204成人電影 免費性愛貼片 走光照

Anónimo dijo...

Judge not a book by its cover...................................................

采瑩采瑩 dijo...

Never put both feet in your mouth at the same time, because then you will not have a leg to stand on. ....................................................

Anónimo dijo...

閒來無聊逛逛blog~~跟您打聲招呼~~........................................

Anónimo dijo...

成功的第一要素是珍惜自己 ............................................................

堅燕 dijo...

哈囉!來拜訪囉~部落格很棒^^~......................................................................

Anónimo dijo...

生存乃是不斷地在內心與靈魂交戰;寫作是坐著審判自己。......................................................................

Anónimo dijo...

死亡是悲哀的,但活得不快樂更悲哀。.................................................................

Anónimo dijo...

幸福不是一切,人還有責任。............................................................

Anónimo dijo...

感謝予我如此動感的blog!..................................................................

Anónimo dijo...

Say not all that you know, believe not all that you hear.............................................................

Anónimo dijo...

責人之心責己,恕己之心恕人。..................................................................

Anónimo dijo...

Some people cannot see the wood for the trees.............................................................

Anónimo dijo...

一時的錯誤不算什麼,錯而不改才是一生中永遠且最大的錯誤............................................................

Anónimo dijo...

Nothing comes from nothing.............................................................

Anónimo dijo...

Share and share alike.............................................................

Anónimo dijo...

No pains, no gains..................................................................

Anónimo dijo...

心中醒,口中說,紙上作,不從身上習過,皆無用也。..................................................

Anónimo dijo...

你不能左右天氣,但你可以改變心情.................................................................

Anónimo dijo...

當最困難的時候,也就是離成功不遠的時候。..................................................

Anónimo dijo...

愛,拆開來是心和受兩個字。用心去接受對方的一切,用心去愛對方的所有。......................................................................

Anónimo dijo...

認清問題就等於已經解決了一半的問題。..................................................

Anónimo dijo...

我是天山,等待一輪明月。......................................................................

Anónimo dijo...

一個人的價值,應該看他貢獻了什麼,而不是他取得了什麼............................................................

Anónimo dijo...

你怎麼能經過一片海,而忘記它的藍?......................................................................

Haider Ali Mussadaq dijo...

I really like your post you done great jobs. Thanks for sharing valuable information.
DNA testing

Kalpesh dijo...

This article is wonderful as it helps me to get the sort of information that i needed.I am thankful as i got your article when was searching Paternity DNA

Unknown dijo...

Hello there, I was searching about t4 ligase and I came across your blog, very informative and entertaining, it shows that your an expert in your field.
I will definitely be back for more. Keep it up!
Cheers!

mogali dijo...

Hiv Test Kit- Home Test Kit for HIV order now. With CE, TUV and ISO Certification. Very accurate blood rapid test for your home. Easy handling, low cost and quick results

elson cade dijo...

The main focus concerns the diagnosis of hereditary diseases
Every paternity establishes a special relationship. This not only means a lifelong emotional bond, but also includes extensive and ongoing legal obligations. As large as the scope of that relationship is, the questions can be just as excruciating if there are any doubts about the Paternity Test, DNA Relationship Test and Identity Proofs. Unlike the mother, as a general rule, the father is naturally often left with his suspicions unless he decides to take a paternity test.